Common symptoms of multiple sclerosis (MS) include motor impairments of the lower extremities, particularly gait disturbances. Loss of balance and muscle weakness, representing some peripheral effects, have been shown to influence these symptoms, however, the individual role of cortical and subcortical structures in the central nervous system is still to be understood. Assessing [18F]fluorodeoxyglucose (FDG) uptake in the CNS can assess brain activity and is directly associated with regional neuronal activity. One potential modality to increase cortical excitability and improve motor (...) function in patients with MS (PwMS) is transcranial direct current stimulation (tDCS). However, tDCS group outcomes may not mirror individual subject responses, which impedes our knowledge of the pathophysiology and management of diseases like MS. Three PwMS randomly received both 3 mA tDCS and SHAM targeting the motor cortex (M1) that controls the more-affected leg for 20 min on separate days before walking on a treadmill. The radiotracer, FDG, was injected at minute two of the 20 min walk and the subjects underwent a Positron emission tomography (PET) scan immediately after the task. Differences in relative regional metabolism of areas under the tDCS anode and the basal ganglia were calculated and investigated. The results indicated diverse and individualized responses in regions under the anode and consistent increases in some basal ganglia areas (e.g., caudate nucleus). Thus, anodal tDCS targeting the M1 that controls the more-affected leg of PwMS might be capable of affecting remote subcortical regions and modulating the activity (motor, cognitive, and behavioral functions) of the circuitry connected to these regions. (shrink)

Acute exercise consistently benefits both emotion and cognition, particularly cognitive control. We evaluated acute endurance exercise influences on emotion, domain-general cognitive control, and the cognitive control of emotion, specifically cognitive reappraisal. Thirty-six endurance runners, defined as running at least 30 miles per week with one weekly run of at least 9 miles (21 female, age 18-30 years) participated. In a repeated measures design, participants walked at 57% age-adjusted maximum heart rate (HRmax) (range 51-63%) and ran at 70% HRmax (range 64-76%) (...) for 90 minutes on two separate days. Participants completed measures of emotional state and the Stroop test of domain-general cognitive control before, every 30 minutes during, and 30 minutes after exercise. Participants also completed a cognitive reappraisal task after exercise. Functional near-infrared spectroscopy tracked changes in oxygenated and deoxygenated hemoglobin levels in the prefrontal cortex (PFC). Endurance exercise elevated positive emotion and cognitive reappraisal success. Endurance exercise reduced Stroop response time and test-evoked PFC oxygenation during exercise. Results suggest that even at relatively moderate intensities, endurance athletes benefit emotionally from running both during and after exercise, and task-related prefrontal cortex oxygenation reductions do not appear to hinder prefrontal-dependent cognitive control. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Night ShiftCalvin R. GrossI don't like working at night anymore. Too much goes wrong when you're alone.I'm sitting at my desk in the middle of the cardiac intensive care unit, and it's far later than I'd like to be awake—two or three in the morning. Things are calm, almost pleasant. I can hear the occasional alarm going off—an imperfectly positioned blood pressure cuff, a pulse oximeter with a poor (...) waveform, a ventilator with secretions in it. The night's initial frenzied work is done; my new admissions are tucked away, and my overnight to-dos are completed. Now it's just time to sit and wait. I could sleep, but despite the calm, I'm too afraid to leave the unit to rest. The fellow has gone to bed hours ago, and now it's just me. Sure, I'm surrounded by experienced nurses who know their work well, but somehow, I'm the one in charge. A brand-new second-year resident, the only doctor there. I'm no intern, that's for sure, but I've never led a code before, and I've only ever placed one central line without supervision. As second years go, I'm as fresh as they come.The daytime, you see, is far different than nights. There's a large (and even bloated) team of two attendings, two fellows, two pharmacists, and more importantly, multiple other residents. When you don't know what to do for a patient, there's always someone there to bounce ideas off of. When something difficult or surprising happens, there are peers and mentors to process with. At night, it's the opposite—no peers, no mentors, only a group of experienced nurses, whose circle is closed to me, the outsider. I long to be a part of that large and bloated daytime team."Can you come into 23? I think his pupils are a different size."I'm startled out of my thoughts. 23 … All I can remember from sign-out that evening is that he's young, close to my age, and supposedly stable. I look at my notes, a catalogue of tragedies: early onset heart failure, multiple prior suicide attempts, intubated because of pulmonary edema, and a left-ventricular assist device (LVAD) that's malfunctioning. I walk over to the room and look at the nurse at the other side of the bed. She's in the early phases of her career too—less than a year on the job—but she's still more experienced than me. I take a flashlight, open his eyelids, and look at the pupils. Sure enough, one of them is much larger than the other. When I shine the light into each eye, the large one doesn't change. When I turn his head from side to side, his eyes stay fixed. We look [End Page 83] at each other, she and I. We both know something terrible is happening."Should we maybe wake the fellow up?" she asks tentatively.I nod my head in agreement, glad to have been offered a suggestion. It's the right thing to do. I walk to the fellow's call room, knock on the door, and wake him up. He's set to work 24 hours and would like nothing more than to keep resting. He sleepily comes with me to the bedside, looks at the pupils as well, and says, "With the sedation on, your exam isn't going to be the most accurate. We should start by scanning his head, and then go from there. Wake me back up if you need me, but I know you've got this one."I don't think that I deserve the confidence he has in me. I walk back to my desk, open the patient's chart, and place the order for an urgent CT scan. The machinery of the hospital starts to rumble as the imaging schedulers find a spot in the queue for the scan, the patient's nurse and respiratory therapist disconnect and reconnect cables and tubes, the technicalities of the scan are ironed out, and he is... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 21.1 (2001) 151-154 [Access article in PDF] Book Review The Happiness Project: Transforming the Three Poisons that Cause the Suffering We Inflict on Ourselves and Others The Happiness Project: Transforming the Three Poisons that Cause the Suffering We Inflict on Ourselves and Others. By Ron Leifer, M.D. Ithaca, New York: Snow Lion, 1997.313 pp. This book focuses mostly on Buddhism and psychotherapy, but it ranges widely and (...) includes many reflections on Christianity. Today there are many good books that compare Buddhism with Western psychology, but this one is not to be missed by anyone interested in the topic. Leifer (a former colleague and friend of Ernest Becker, who wrote TheDenial ofDeath) is obviously a very experienced psychiatrist, with deep knowledge of psychoanalytic theory to supplement his many years of practice [End Page 151] as a therapist. This book is many things: a primer on demythologized Buddhism; a superior "self-help" book; a history of psychotherapy, including a critique of its modern medicalization; a speculative account of the evolution of human consciousness; and, not least, the most insightful interpretations of the Job, Oedipus, and Eden myths that I have encountered. The prose style is lucid, and only space limitations keep me from quoting it at length.The title turns out to be ironic, since our Happiness Projects are the main source of our unhappiness. Our selfish strivings for happiness are, paradoxically, the main cause of the suffering we inflict on ourselves and others.What we "fail to see" (avidya)is not some great mysterious wisdom. "The core of the esoteric knowledge we seek consists of secrets we hide from ourselves. We hide from them because they are not what we want them to be. The world is not what we want it to be. Life is not what we want it to be. Others are not what we want them to be. We are not ourselves what we want to be. We hide from these truths because they mystify and terrify us" (12). The basic "secret" of happiness is that the three poisons--greed, ill will, and ignorance--are the source of our pain and suffering, by creating rebounding karmic ripples. The ego is a trickster who is continually the victim of his own trickery. True happiness can only be the product of an inner transformation that changes our habitual patterns of thought and action, enabling us to "relax into existence." Leifer's psychologized Buddhism is a therapeutic path cleansed of the mystical and paranormal; there is no place here for psychic powers or any transcendental salvation (nirvana is not discussed). The focus throughout is on how we are bedeviled by our own desires.The book is organized into four main parts. The first offers Leifer's understanding of the first two Buddhist truths. The second part, "Western Views of Suffering," includes profound interpretations of Job and Oedipus Rex. Job's suffering illustrates the first truth, that life is suffering, and his patience is virtuous, even heroic, in its refusal to demand that life be different than it is--an endurance that allows him to avoid making life worse: "Patience is the willingness to suffer without aggression" (131).The key to the Oedipus story is in his answer to the Sphinx's riddle: humans are the creatures who walk on four legs as infants, on two legs as mature adults, and then on three legs (with a cane) in old age. The riddle is a metaphor for the truths of our impermanence, old age and death. But Oedipus cannot accept it. "From a Buddhist point of view, the story of Oedipus is a metaphor for neurotic mind. Oedipus was the victim of his own grasping ego--of his desires and aggressions. His fate was sealed by his own efforts to escape it. The source of Oedipus' pain and tragedy were his own ignorance, passion, and aggression: the three poisons" (135). His desire for Mom is better understood as a symbol of human desire generally: our refusal to grow up... (shrink)

XLRI, in association with a few Tata Group companies, established the XLRI-JRD Tata Foundation in Business Ethics in 1991 to mark their long-standing commitment and contribution to business ethics in India. The foundation seeks to address this by publicly affirming the urgent need for ethics in business and the need to bring about a conducive culture in which it can thrive.

Hicks' edition of the De Anima contains valuable commentary from Hicks as well as useful summaries of the views of earlier commentators.

Originally delivered as lectures directed towards a largely lay audience, this series of ten papers deals with certain representative advances in modern science which most radically affect man's view of the world. To ensure a fair sample or cross section, three are roughly philosophical, three are concerned with the relation of science to public policy, three look to the future, with a final paper reporting experimental research together with brief speculation relative to there being life on other worlds. Since most (...) of the papers are quite brief, they have had to choose between breadth of coverage and depth discussion. Philosophically the most interesting is Ernan McMullin's "Limits of Scientific Inquiry." The ten lectures were originally delivered at Georgetown University as part of the commemoration of its 175th anniversary.--R. D. (shrink)

Requests by patients or their families for treatment which the patient's physician considers to be "inappropriate" are becoming more frequent than refusals of treatment which the physician considers appropriate. Such requests are often based on the patient's religious beliefs about the attributes of God (sovereignty, omnipotence), the attributes of persons (sanctity of life), or the individual's personal relationship with God (communication, commands, etc). We present four such cases and discuss some of the basic religious tenets of the three Abrahamic faith (...) traditions as they relate to such requests. We suggest that religious reasons for requesting "inappropriate" treatment are "special" and deserve serious consideration. We offer guidance to assist clinicians and clinical ethicists as they attempt to resolve these conflicts, emphasising the importance of understanding the religious beliefs of the patient/surrogate and suggesting the assistance of a religious interpreter. We suggest open discussion with patients and families of both the clinical situation and the theological basis for these requests. We also suggest that clinicians use additional religious doctrines or principles from patients' own traditions to balance the reasons behind the requests. We conclude that most persistent requests for "inappropriate" treatment should be honoured. (shrink)

We show there is only one consistent way to update a probability assignment, that given by Bayes's rule. The price of inconsistent updating is a loss of efficiency. The implications of this for the problem of induction are discussed.

The dialectical method used in this work to clarify the issues and to render "an objective, impartial, and neutrally formulated report" is a model for analysis and is valuable in itself. Its application, in Book II, yields a well-documented presentation of almost all the important thinkers on freedom. First modes of possession and then modes of the self are viewed as characterizing this idea. The forty-page bibliography of works referred to or examined adds to the usefulness of the study and (...) indicates its scope.--R. D. G. (shrink)

R D Smith; The Use of Memory, Journal of Philosophy of Education, Volume 17, Issue 1, 30 May 2006, Pages 85–96, https://doi.org/10.1111/j.1467-9752.1983.tb00018.

In this book, Anthony R. D'Augelli and Charlotte J. Patterson bring together top experts to offer a comprehensive overview of what we have discovered--and what we still need to learn--about lesbian, gay, and bisexual identities.

The broad analysis made by Home and Watanabe of the development of physics in Australia during the period from 1914 to 1945 is generally accepted; however, details relating to the backgrounds of certain of these developments are questioned.

"This study attempts to evaluate some main trends in Soviet Marxism in terms of an 'immanent critique,' that is to say it starts from the theoretical premises of Soviet Marxism, develops their ideological and sociological consequences, and reexamines the premises in the light of these consequences." In two sections the author treats "Political Tenets" and the too seldom presented Soviet Ethics, which is most striking for its externalization of values and paucity of content. Written neither for the political theorist nor (...) the ethicist, the work while popular and often superficial presents an interesting and frequently illuminating study. --R. D. G. (shrink)

The Rector of the University of Buenos Aires here briefly outlines and criticizes some of the present-day subjectivist and objectivist positions, and suggests a means of reconciling the two. --R. D. G.

It is possible to retrieve viable sperm from a dying man or from a recently dead body. This sperm can be frozen for later use by his wife or partner to produce his genetic offspring. But the technical feasibility alone does not morally justify such an endeavour. Posthumous semen retrieval raises questions about consent, the respectful treatment of the dead body, and the welfare of the child to be.We present two cases, discuss these three issues, and conclude that such requests (...) should generally not be honoured unless there is convincing evidence that the dead man would want his widow to carry and bear his child. Even with consent, the welfare of the potential child must be considered. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:R. D. Ackerman BELIEVING IN A FICTION: WALLACE STEVENS AT THE LIMITS OF PHENOMENOLOGY The "ring of men" of "Sunday Morning" will chant their "devotion to the sun, / Not as a god, but as a god might be, / Naked among them, like a savage source" (CP, pp. 69-70).' Solar nakedness is deferred even as it is named. The problem for belief is the question of appearance and (...) representation. Things appear as and like.... The phenomenological return to things is also a turn to fiction, as Husserl understood: "If anyone loves a paradox, he can really say... that the element which makes up the life of phenomenology... is fiction. ' " The sun is divine, and it is not; it is both naked and clothed, savage and civilized, source (or end) and means. But such paradox is ultimately unsatisfying, and as we will see with Stevens, the need for belief—for an image or idea of totality—forces the issue of fiction and reality. The Stevens we will have in view is not the Stevens—as if there were such a creature. Our Stevens is the one most persuaded by promises such as those of phenomenology, the one most concerned with decreation (reduction) and fresh beginnings, with discovery and recognition, with imagination, the body, and the earth. This is the Stevens for whom the barrier of language presages at last not absence and difference but fictive recovery of presence and identity, the one for whom poetry represents a way of belief beyond mysticism even as it bodes mythic proximity. Finally, this is the Stevens who predominates throughout the prose (as well as in much of the poetry), who tries mightily to secure a belief while disencumbering himself of metaphysics—but alas, I think, with small success. Although Stevens's association of the problem of belief with the idea of fiction occurs in early poems such as "A High-Toned Old Christian 79 80Philosophy and Literature Woman" and "To the One of Fictive Music," his most intensive involvement with fiction as belief dates from the early 1940s and spans the period of his major essays and his last four volumes of poems. He recounts, for instance, a 1942 conversation with a student: "I said that I thought that we had reached a point at which we could no longer really believe in anything unless we recognized that it was a fiction. The student said that that was an impossibility, that there was no such thing as believing in something that one knew was not true. It is obvious, however, that we are doing that all the time" (L, p. 430). What does it mean to believe in a fiction? That is my main subject here, as we seek out the limits of the phenomenological Stevens. His letters of this period are preoccupied with the problem of fictive belief: "If one no longer believes in God (as truth), it is not possible merely to disbelieve; it becomes necessary to believe in something else.... A good deal of my poetry recently has concerned an identity for that thing.... In one of the short poems that I have just sent to the harvard advocate, I say that one's final belief must be in a fiction. I think that the history of belief will show that it has always been in a fiction" (L, p. 370). The poem referred to, "Asides on the Oboe," begins: The prologues are over. It is a question now, Of final belief. So, say that final belief Must be in a fiction. It is time to choose. (CP, p. 250) Acknowledging that "in the long run, poetry would be the supreme fiction" (L, pp. 430-31), Stevens nonetheless singles out the nominative function of poetry as the essence of its claim to supremacy: "Poetry means not the language of poetry but the thing itself.... The subject matter is what comes to mind when one says of the month of August... 'Thou art not August, unless I make thee so'" (L, p. 377). The quoted line (also from "Asides") underscores the paradox that for Stevens the essence of fiction (the nontrue) is its capacity to nominate the true or the real. This... (shrink)

Written from the viewpoint of contemporary philosophical analysis, this book provides a simple--and biased--introduction "to philosophical thinking for those students of education in universities and training colleges who would otherwise have no formal contact with philosophy."--R. D. G.

"The absolute is the total existence, the last key to existence is existence itself, the fact of existing. That does not say definitely anything. On the contrary it is an imprecise statement," the author tells us. But he does not elaborate.--R. D. G.

Newly translated and revised, this book is as pertinent today as when it first appeared in 1930. In it Maritain presents some striking aspects of the personality and work of Aquinas and shows the continued relevance of Thomism. A generous appendix includes bibliographies and reprints of four pertinent papal documents.--R. D. G.

A useful edition of some political and strategic writings, together with all the significant philosophical essays of Mao Tse-tung, who is described as the "most influential" contemporary Marxist philosopher. Except for the 1957 "Hundred Flowers" speech, all the translations and footnotes are from International Publishers' four volume Selected Works. Miss Fremantle's forty-one page introduction is largely a paraphrased abridgment of Edgar Snow's well known biography, Red Star over China. For the general reader, this Mentor paperback probably provides the best low (...) priced introduction to the thought of Mao Tse-tung.--K. R. D. (shrink)

This volume in the "World Perspectives" series brings together four chapters from The Concept of Nature and one each from The Principle of Relativity, The Principles of Natural Knowledge, Modes of Thought, and Essays in Science and Philosophy.--K. R. D.

The third volume in a projected library of contemporary Soviet thought called 'Sovietica' is of particular interest because it makes available to non-Russian readers a condensed German translation of the most recent Summa of Soviet thought, Osnovy marksistskoj filosofii. The text, organised under two main headings, Dialectical and Historical Materialism, is a catechism of Soviet dogmata which ranges from questions of space, time and perception to those of scientific socialism, class war and social consciousness. One of the aims of the (...) editor, as stated in the preface, is to demonstrate that the current Soviet version of 'Marxism' fails to express young Marx's overriding concern for the human being, and the phenomenon of estrangement.--K. R. D. (shrink)

The fourth volume of the 'Sovietica' series is chiefly composed of a collection in German translation of four papers read at a Moscow conference in 1958. The theme of the conference was 'The Question of Dialectical Contradiction in the Light of Contemporary Science and Practice.' Included are a brief excerpt from the official Soviet textbook, Osnovy marksistkoj filosofii and a noteworthy paper by A. I. Kolman.--K. R. D.

The first systematic study printed in the recently inaugurated "Sovietica" series, edited by J. M. Bochenski. In this volume, the author examines the basic theses of dialectical materialism and reviews the efforts of Soviet philosophers and physicists to accomodate their official philosophical framework to the challenge of Einstein's special relativity theory. The excellent handling of this subject owes much to the author's masterly grasp of physics, philosophy, and Russian.--K. R. D.

A new journal issued in connection with the Hegel-Kommission der Deutschen Forschungsgemeinschaft, which is preparing a new critical-historical collection of Hegel's works. The first volume contains critical editions of certain Hegel fragments, essays on Hegel, and reviews of Hegel literature.--K. R. D.

A significant advance toward a more objective understanding of western philosophy in Soviet philosophical circles. Unlike the off-hand condemnations of western philosophers which so often fill the pages of Voprosy Filosofii, this Georgian philosopher presents a well documented historical development of twentieth century analytic philosophy from Russell's atomism, through Wittgenstein's Tractatus, logical positivism, and recent trends in English analysis. The "moral" of the story is that western thinkers are gradually coming to see the poverty of their philosophical perspective; linguistic analysis (...) must give way to the "precise vision of historical materialism."--K. R. D. (shrink)

A selection of articles originally written in English for the New York Tribune and here edited with an eye to proving the tantalizing thesis "that for Karl Marx antagonism between capital and labor took second place to the eternal duel between East and West, in which his sympathies... lay unequivocally with the West." Although these articles, dealing mainly with the Crimean War, merit greater attention than they have thus far received, this edition is misleading in two critical aspects: 1) Many (...) of the articles signed by Marx in the New York Tribune, especially those dealing with military affairs, were actually written by Engels. The crucial document for distinguishing them, a notebook kept by Marx's wife, is acknowledged to be in Moscow, but the editor makes no mention of this. 2) The editor also gives no hint of Marx's many other statements on Russia, especially in his preface to the second edition of Capital and in his correspondence with Vera Zasulich.--K. R. D. (shrink)